CANCERS BRONCHIQUES A PETITES CELLULES
TRAITEMENTS BIOLOGIQUES: ANTICOAGULANTS ET ANTIAGREGANTS

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Référence

chimioth.

anticoag.

modalité

stade

nb pts

SM CT

SM CT+ anti

p

Chahinian,

1989

MTX-ADR-CPA-CCNU

warfarine

induction

ME

189

8m

9m

NS

Lebeau,

1993

CPA-CCNU-ADR-VP16

aspirine

induction

18 mois

tous

303

285j

282j

NS

Lebeau,

1994

CPA-ADR-VP16-CCNU

héparine SC

induction

5 sem

tous

277

261j

317j

0,01

Maurer,

1997

ADR-CPA-VP16

warfarine

induction

6 mois

ML

369

19m

21m

NS



Références
  1. Chahinian AP, Propert KJ, Ware JH, Zimmer B, Perry MC, Hirsh V et al. A randomized trial of anticoagulation with warfarin and of alternating chemotherapy in extensive small-cell lung cancer by the Cancer and Leukemia Group B [see comments]. J Clin Oncol 1989; 7(8):993-1002.

  2. Lebeau B, Chastang C, Muir JF, Vincent J, Massin F, Fabre C. No effect of an antiaggregant treatment with aspirin in small cell lung cancer treated with CCAVP16 chemotherapy. Results from a randomized clinical trial of 303 patients. The "Petites Cellules" Group. Cancer 1993; 71(5):1741-1745.

  3. Lebeau B, Chastang C, Brechot JM, Capron F, Dautzenberg B, Delaisements C et al. Subcutaneous heparin treatment increases survival in small cell lung cancer. "Petites Cellules" Group. Cancer 1994; 74(1):38-45.

  4. Maurer LH, Herndon JE, Hollis DR, Aisner J, Carey RW, Skarin AT et al. Randomized trial of chemotherapy and radiation therapy with or without warfarin for limited-stage small-cell lung cancer: a Cancer and Leukemia Group B study. J Clin Oncol 1997; 15(11):3378-3387.


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