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CANCERS BRONCHIQUES A PETITES CELLULES
TRAITEMENTS BIOLOGIQUES: ANTICOAGULANTS ET ANTIAGREGANTS
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Référence |
chimioth. |
anticoag. |
modalité |
stade |
nb pts |
SM CT |
SM CT+ anti |
p |
Chahinian,
1989 |
MTX-ADR-CPA-CCNU |
warfarine |
induction |
ME |
189 |
8m |
9m |
NS |
Lebeau,
1993 |
CPA-CCNU-ADR-VP16 |
aspirine |
induction
18 mois |
tous |
303 |
285j |
282j |
NS |
Lebeau,
1994 |
CPA-ADR-VP16-CCNU |
héparine SC |
induction
5 sem |
tous |
277 |
261j |
317j |
0,01 |
Maurer,
1997 |
ADR-CPA-VP16 |
warfarine |
induction
6 mois |
ML |
369 |
19m |
21m |
NS |
Références
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Chahinian AP, Propert KJ, Ware JH, Zimmer B, Perry MC, Hirsh V et al. A randomized trial of
anticoagulation with warfarin and of alternating chemotherapy in extensive small-cell lung
cancer by the Cancer and Leukemia Group B [see comments]. J Clin Oncol 1989; 7(8):993-1002.
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Lebeau B, Chastang C, Muir JF, Vincent J, Massin F, Fabre C. No effect of an antiaggregant
treatment with aspirin in small cell lung cancer treated with CCAVP16 chemotherapy. Results
from a randomized clinical trial of 303 patients. The "Petites Cellules" Group.
Cancer 1993; 71(5):1741-1745.
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Lebeau B, Chastang C, Brechot JM, Capron F, Dautzenberg B, Delaisements C et al. Subcutaneous
heparin treatment increases survival in small cell lung cancer. "Petites Cellules" Group.
Cancer 1994; 74(1):38-45.
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Maurer LH, Herndon JE, Hollis DR, Aisner J, Carey RW, Skarin AT et al. Randomized trial of
chemotherapy and radiation therapy with or without warfarin for limited-stage small-cell
lung cancer: a Cancer and Leukemia Group B study. J Clin Oncol 1997; 15(11):3378-3387.
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