|
CANCERS BRONCHIQUES A PETITES CELLULES
TRAITEMENTS BIOLOGIQUES: INTERFERONS |
|
|
Référence |
chimiothérapie |
IFN |
modalité |
stade |
nb pts |
SM CT |
SM CT + IFN |
p |
|
Mattson, 1992 |
CPA-VCR-VP16 |
a 6 m |
entretien |
tous |
237 |
11m |
11m |
NS |
|
Jett, 1994 |
CDDP-VP16 |
g 6 m |
entretien RC |
tous |
100 |
19m |
13m |
NS |
|
Kelly, 1995 |
CDDP-VP16 + RT |
a 2 ans |
entretien RO |
ML |
133 |
10m |
9m |
NS |
|
Zarogoulidis, 1996 |
CBDCA-Ifo-VP16 |
a CT |
induction 6-8 m |
tous |
45 |
11m |
10m |
NS |
|
van Zandwijk 1997 |
divers |
g 4 m |
entretien RC |
tous |
120 |
10m |
9m |
NS |
|
Prior, 1997 |
VAC~CDDP-VP16 |
a 6 m |
induction 6 m |
tous |
77 |
9m |
11m |
0,02 |
|
Ruotsalainen, 1999 |
CDDP-VP16 |
I. a CRII. a Roche |
induction |
tous |
219 |
10 m |
10 m 10 m |
NS |
Références
(1) Mattson K, Niiranen A, Pyrhonen S, Holsti LR, Holsti P, Kumpulainen E et al. Natural interferon alfa as maintenance therapy for small cell lung cancer. Eur J Cancer 1992; 28A(8-9):1387-1391.
(2) Jett JR, Maksymiuk AW, Su JQ, Mailliard JA, Krook JE, Tschetter LK et al. Phase III trial of recombinant interferon gamma in complete responders with small-cell lung cancer. J Clin Oncol 1994; 12(11):2321-2326.
(3) Kelly K, Crowley JJ, Bunn PAJ, Hazuka MB, Beasley K, Upchurch C et al. Role of recombinant interferon alfa-2a maintenance in patients with limited-stage small-cell lung cancer responding to concurrent chemoradiation: a Southwest Oncology Group study. J Clin Oncol 1995; 13(12):2924-2930.
(4) Zarogoulidis K, Ziogas E, Papagiannis A, Charitopoulos K, Dimitriadis K, Economides D et al. Interferon alpha-2a and combined chemotherapy as first line treatment in SCLC patients: a randomized trial. Lung Cancer 1996; 15(2):197-205.
(5) van Zandwijk N, Groen HJ, Postmus PE, Burghouts JT, ten Velde GP, Ardizzoni A et al. Role of recombinant interferon-gamma maintenance in responding patients with small cell lung cancer. A randomised phase III study of the EORTC Lung Cancer Cooperative Group [see comments]. Eur J Cancer 1997; 33(11):1759-1766.
(6) Prior C, Oroszy S, Oberaigner W, Schenk E, Kummer F, Aigner K et al. Adjunctive interferon-alpha-2c in stage IIIB/IV small-cell lung cancer: a phase III trial [published erratum appears in Eur Respir J 1997 Apr;10(4):963]. Eur Respir J 1997; 10(2):392-396.
(7) Ruotsalainen TM, Halme M, Tamminen K, Szopinski J, Niiranen A, Pyrhonen S et al. Concomitant chemotherapy and IFN-alpha for small cell lung cancer: a randomized multicenter phase III study. J Interferon Cytokine Res 1999; 19(3):253-259.