|
CANCERS BRONCHIQUES A PETITES CELLULES
ESSAIS TESTANT L’IRRADIATION THORACIQUE EN ALTERNANCE DANS LES MALADIES LIMITEES |
|
|
Référence |
chimiothérapie |
bras |
radiothérapie |
n pts |
SM |
p |
|
Gregor, 1997 |
CPA-ADR-VP16 (x5) |
- alternance |
12 Gy (en 5x) J15 #2,3,4,5 |
169 |
14 m |
NS |
|
- séquentiel (après CT) |
50 Gy/20x/4s |
165 |
15 m |
|||
|
Lebeau, 1999 |
CPA-ADR-VP16-VDS |
- concomitant |
3è cure : 50 Gy |
82 |
13m |
NS |
|
- alternance |
2è, 3è, 4è cures : 20, 20 et 15 Gy |
74 |
14m |
Références
(1) Gregor A, Drings P, Burghouts J, Postmus PE, Morgan D, Sahmoud T et al. Randomized trial of alternating versus sequential radiotherapy/chemotherapy in limited-disease patients with small-cell lung cancer: a European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group Study. J Clin Oncol 1997; 15(8):2840-2849.
(2) Lebeau B, Urban T, Brechot JM, Paillotin D, Vincent J, Leclerc P et al. A randomized clinical trial comparing concurrent and alternating thoracic irradiation for patients with limited small cell lung carcinoma. "Petites Cellules" Group. Cancer 1999; 86(8):1480-1487.