CANCERS BRONCHIQUES A PETITES CELLULES
ESSAIS COMPARANT LA PLACE PRECOCE OU TARDIVE DE L’IRRADIATION THORACIQUE DANS LES MALADIES LIMITEES

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Référence

chimiothérapie

radiothérapie

bras

n pts

SM

p

Perry,

1987(1)

CPA-VCR- ADR/VP16

50 Gy/25x/5 s

- initiale (J1)

125

13,1 m

 

NS

- tardive (# 4)

145

14,6 m

Murray,

1993 (2)

CPA-VCR-ADR ~ CDDP-VP16

40 Gy/15x/2 s

- initiale (s 3)

155

21,2 m

 

0,008

- tardive(>#6)

153

16 m

Jeremic,

1997 (3)

CDDP-VP16

54 Gy (2x /j)/ 36x/18j/3,6 s

- initiale (J1)

52

34 m

 

0,05

- tardive (s 6)

51

26 m

Work,

1997 (4)

CDDP-VP16 ~ ADR-CPA- VCR

40-45 Gy split

2 x 11x/ 2 s

- initiale (J1)

99

10,5 m

 

NS

- tardive(> #6)

100

12 m

Skarlos,

2001 (5)

Carboplatine – VP16

HFRT  48 Gy

1,8 Gy bid 15 x

-initiale (cycle 1)

42

17 m

 

NS

-tardive (cycle 4)

39

17 m

Takada,

2002 (6)

CDDP-VP16 (4 cycles)

HFRT  45 Gy

1,5 Gy 2x/j en 3 sem

- initiale (J2)

114

27,2 m

 

0;097

- tardive (après CT)

114

19,7 m

Spiro,

2006 (7)

CPA-VCR-ADR ~ CDDP-VP16 (3 x 2 alt)

40 Gy/15x/3 s

-initial (2è cycle)

159

13,7 m

 

0,23

- tardif (6è cycle)

166

15,1 m

Hu,

2012 (8)

CDDP-VP6 x 6

55 Gy/30x / 19J après 2 cycles

- volume initial

43

25,4 m

0,54

- volume réduit

42

22,1 m

Sun,

2013 (9)

CDDP-VP6 x 6 x 4

52,5 Gy / 5 sem

- 1er cycle

113

26,8 m

NS

- 3è cycle

109

24,1 m



Références

(1) Perry MC, Eaton WL, Propert KJ, Ware JH, Zimmer B, Chahinian AP et al. Chemotherapy with or without radiation therapy in limited small-cell carcinoma of the lung. N Engl J Med 1987; 316(15):912-918.

(2) Murray N, Coy P, Pater JL, Hodson I, Arnold A, Zee BC et al. Importance of timing for thoracic irradiation in the combined modality treatment of limited-stage small-cell lung cancer. The National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 1993; 11(2):336-344.

(3) Jeremic B, Shibamoto Y, Acimovic L, Milisavljevic S. Initial versus delayed accelerated hyperfractionated radiation therapy and concurrent chemotherapy in limited small-cell lung cancer: a randomized study. J Clin Oncol 1997; 15(3):893-900.

(4) Work E, Nielsen OS, Bentzen SM, Fode K, Palshof T. Randomized study of initial versus late chest irradiation combined with chemotherapy in limited-stage small-cell lung cancer. Aarhus Lung Cancer Group. J Clin Oncol 1997; 15(9):3030-3037.

(5) Skarlos DV, Samantas E, Briassoulis E, Panoussaki E, Pavlidis N, Kalofonos HP et al. Randomized comparison of early versus late hyperfractionated thoracic irradiation concurrently with chemotherapy in limited disease small-cell lung cancer: a randomized phase II study of the Hellenic Cooperative Oncology Group (HeCOG). Ann Oncol 2001; 12(9):1231-1238.

(6) Takada M, Fukuoka M, Kawahara M, Sugiura T, Yokoyama A, Yokota S et al. Phase III Study of Concurrent Versus Sequential Thoracic Radiotherapy in Combination With Cisplatin and Etoposide for Limited-Stage Small-Cell Lung Cancer: Results of the Japan Clinical Oncology Group Study 9104. J Clin Oncol 2002; 20(14):3054-3060.

(7) Spiro SG, James LE, Rudd RM, Trask CW, Tobias JS, Snee M et al. Early compared with late radiotherapy in combined modality treatment for limited disease small-cell lung cancer: a London Lung Cancer Group multicenter randomized clinical trial and meta-analysis J Clin Oncol 2006; 24(24):3823-3830

(8) Hu X, Bao Y, Zhang L, Guo Y, Chen YY, Li KX, et al. Omitting elective nodal irradiation and irradiating postinduction versus preinduction chemotherapy tumor extent for limited-stage small cell lung cancer: interim analysis of a prospective randomized noninferiority trial. Cancer 2012 Jan 1;118(1):278-87.

(9) Sun JM, Ahn YC, Choi EK, Ahn MJ, Ahn JS, Lee SH, et al. Phase III trial of concurrent thoracic radiotherapy with either first- or third-cycle chemotherapy for limited-disease small-cell lung cancer. Ann Oncol 2013 Aug;24(8):2088-92



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