|
CANCERS BRONCHIQUES A PETITES CELLULES
TRAITEMENTS BIOLOGIQUES: INHIBITEURS DE TYROSINE KINASE |
|
|
Référence |
chimiothérapie |
TKI |
modalité |
stade |
nb pts |
SM CT |
p |
|
Arnold (1) |
RO à chimio
(+/- RT) |
vandetanib
oral 300 mg |
entretien |
tous |
53 |
10,6 m |
NS |
|
placebo |
54 |
11,9 m |
Références
(1) Arnold AM, Seymour L, Smylie M, Ding K, Ung Y, Findlay B, et al. Phase II study of vandetanib or placebo in small-cell lung cancer patients after complete or partial response to induction chemotherapy with or without radiation therapy: National Cancer Institute of Canada Clinical Trials Group Study BR.20. J Clin Oncol 2007 Sep 20;25(27):4278-84.