|
CANCERS BRONCHIQUES A PETITES CELLULES
ESSAIS TESTANT LA CHIRURGIE DANS LES MALADIES LIMITEES |
|
|
Référence |
bras |
Schéma |
n pts |
R0 |
SM |
p |
|
Fox, 1966 &1973 |
- chirurgie |
82 |
199 j |
|
||
|
- radiothérapie |
Minimum 30 Gy |
84 |
48% |
300 j |
||
|
Lad, 1994 |
- chirurgie |
5 cycles chimio d’induction avec CPA + VCR + ADR |
70 |
83% |
NS |
|
|
- sans chirurgie |
74 |
Références
(1) Comparative trial of surgery and radiotherapy for the primary treatment of small-celled or oat-celled carcinoma of the bronchus. First report to the Medical Research Council by the working-party on the evaluation of different methods of therapy in carcinoma of the bronchus. Lancet 1966; 2(7471):979-986.
(2) Fox W, Scadding JG. Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small-celled or oat-celled carcinoma of bronchus. Ten-year follow-up. Lancet 1973; 2(7820):63-65.
(3) Lad T, Piantadosi S, Thomas P, Payne D, Ruckdeschel J, Giaccone G. A prospective randomized trial to determine the benefit of surgical resection of residual disease following response of small cell lung cancer to combination chemotherapy. Chest 1994; 106(6 Suppl):320S-323S.