CANCERS BRONCHIQUES A PETITES CELLULES
IRRADIATION CEREBRALE PREVENTIVE

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Référence

stade

modalité

Dose Gy

N pts

Effet sur rechutes cérébrales

Effet sur survie

Jackson, 1977 (1)

Tous

Initiale

30

29

NS

NS

Beiler,

1979 (2)

Tous

Initiale

24

54

NS

NS

Hansen,

1980 (3)

ML

Consolidation

40

109

 

NS

Maurer,

1980 (4)

Tous

Initiale

30

153

S

NS

Eagan,

1981 (5)

ML

Consolidation

36

30

 

NS

Aisner,

1982 (6)

Tous

Rémission complète

30

29

NS

NS

Seydel,

1985 (7)

ML

Initiale

30

217

NS

NS

Niiranen,

1989 (8)

ML

Initiale

40

51

NS

NS

Ohonoshi,

1993 (9)

Tous

Rémission complète

40

46

NS

NS

Arriagada,

1995 (10)

Tous

Rémission complète

24

294

S

NS

Gregor,

1997 (11)

ML

Rémission complète

8 - 40

314

S

NS

Laplanche,

1998 (12)

Tous

Rémission complète

24

211

NS

NS

Slotman,

2007 (13)

ME

Réponse (de tout type)

25 - 39

246

S

S



Références

(1) Jackson DV, Jr., Richards F, Cooper MR, Ferree C, Muss HB, White DR et al. Prophylactic cranial irradiation in small cell carcinoma of the lung. A randomized study. JAMA 1977; 237(25):2730-2733.

(2) Beiler DD, Kane RC, Bernath AM, Cashdollar MR. Low dose elective brain irradiation in small cell carcinoma of the lung. Int J Radiat Oncol Biol Phys 1979; 5(7):941-945.

(3) Hansen HH, Dombernowsky P, Hirsch FR, Hansen M, Rygard J. Prophylactic irradiation in bronchogenic small cell anaplastic carcinoma. A comparative trial of localized versus extensive radiotherapy including prophylactic brain irradiation in patients receiving combination chemotherapy. Cancer 1980; 46(2):279-284.

(4) Maurer LH, Tulloh M, Weiss RB, Blom J, Leone L, Glidewell O et al. A randomized combined modality trial in small cell carcinoma of the lung: comparison of combination chemotherapy-radiation therapy versus cyclophosphamide-radiation therapy effects of maintenance chemotherapy and prophylactiv whole brain irradiation. Cancer 1980; 45(1):30-39.

(5) Eagan RT, Frytak S, Lee RE, Creagan ET, Ingle JN, Nichols WC. A case for preplanned thoracic and prophylactic whole brain radiation therapy in limited small-cell lung cancer. Cancer Clin Trials 1981; 4(3):261-266.

(6) Aisner J, Whitacre M, Van Echo DA, Wiernik PH. Combination chemotherapy for small cell carcinoma of the lung: continuous versus alternating non-cross-resistant combinations. Cancer Treat Rep 1982; 66(2):221-230.

(7) Seydel HG, Creech R, Pagano M, Salazar O, Rubin P, Concannon J et al. Prophylactic versus no brain irradiation in regional small cell lung carcinoma. Am J Clin Oncol 1985; 8(3):218-223.

(8) Niiranen A, Holsti P, Salmo M. Treatment of small cell lung cancer. Two-drug versus four-drug chemotherapy and loco-regional irradiation with or without prophylactic cranial irradiation. Acta Oncol 1989; 28(4):501-505.

(9) Ohonoshi T, Ueoka H, Kawahara S, Kiura K, Kamei H, Hiraki Y et al. Comparative study of prophylactic cranial irradiation in patients with small cell lung cancer achieving a complete response: a long-term follow-up result. Lung Cancer 1993; 10(1-2):47-54.

(10) Arriagada R, Le Chevalier T, Borie F, Riviere A, Chomy P, Monnet I et al. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. J Natl Cancer Inst 1995; 87(3):183-190.

(11) Gregor A, Cull A, Stephens RJ, Kirkpatrick JA, Yarnold JR, Girling DJ et al. Prophylactic cranial irradiation is indicated following complete response to induction therapy in small cell lung cancer: results of a multicentre randomised trial. United Kingdom Coordinating Committee for Cancer Research (UKCCCR) and the European Organization for Research and Treatment of Cancer (EORTC). Eur J Cancer 1997; 33(11):1752-1758.

(12) Laplanche A, Monnet I, Santos-Miranda JA, Bardet E, Le Pechoux C, Tarayre M et al. Controlled clinical trial of prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Lung Cancer 1998; 21(3):193-201.

(13) Slotman B, Faivre-Finn C, Kramer G, Rankin E, Snee M, Hatton M, et al. Prophylactic cranial irradiation in extensive small-cell lung cancer. N Engl J Med 2007 Aug 16;357(7):664-72.



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