CANCERS BRONCHIQUES A PETITES CELLULES
CHIMIOTHERAPIE: LE MINIMALISME

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Référence

Chimiothérapie

nb

cures

nb

pts

nb ML

RO

SM

p

MRC,

1993

1.VP16-MTX-CPA-VCR

3

157

90

60%

225j

 

NS

2.VP16-MTX-CPA-VCR

6

152

84

57%

263j

3. Ifo-VP16

6

146

82

66%

269j

MRC,

1996

1.VP16-MTX-CPA-VCR

3

154

43

40%

141j

NS

2. VP16-VCR

3

156

46

46%

137j

MRC,

1996

1. VP16 oral

4

171

70

44%

130j

S

2. VAC ou VP16-VCR

4

168

76

51%

183j

Souhami,

1997

1.VP16 oral

6

75

-

32%

4,8m

S

2. CDDP-VP16~VAC

3x2

80

-

46%

5,9m

Ettinger,

2002

1. CPA-ADR-VCR

 

46

-

56%

42s

 

S

2. Ifosfamide

 

43

-

44%

43s

3. VM26

 

46

-

43%

38s



Références

(1) Bleehen NM, Girling DJ, Machin D, Stephens RJ. A randomised trial of three or six courses of etoposide cyclophosphamide methotrexate and vincristine or six courses of etoposide and ifosfamide in small cell lung cancer (SCLC). I: Survival and prognostic factors. Medical Research Council Lung Cancer Working Party. Br J Cancer 1993; 68(6):1150-1156.

(2) Randomised trial of four-drug vs less intensive two-drug chemotherapy in the palliative treatment of patients with small-cell lung cancer (SCLC) and poor prognosis. Medical Research Council Lung Cancer Working Party [published erratum appears in Br J Cancer 1996 Sep;74(6):997]. Br J Cancer 1996; 73(3):406-413.

(3) Girling DJ. Comparison of oral etoposide and standard intravenous multidrug chemotherapy for small-cell lung cancer: a stopped multicentre randomised trial. Medical Research Council Lung Cancer Working Party [see comments]. Lancet 1996; 348(9027):563-566.

(4) Souhami RL, Spiro SG, Rudd RM, Ruiz dEM, James LE, Gower NH et al. Five-day oral etoposide treatment for advanced small-cell lung cancer: randomized comparison with intravenous chemotherapy [see comments]. J Natl Cancer Inst 1997; 89(8):577-580.

(5) Ettinger DS, Finkelstein DM, Ritch PS, Lincoln ST, Blum RH. Study of either ifosfamide or teniposide compared to a standard chemotherapy for extensive disease small cell lung cancer: an Eastern Cooperative Oncology Group randomized study (E1588). Lung Cancer 2002; 37(3):311-318.



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