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CANCERS BRONCHIQUES A PETITES CELLULES
MAINTIEN DE LA DOSE-INTENSITE PAR LES FACTEURS DE CROISSANCE
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|
Référence |
Schéma |
N pts |
RO |
p |
SM |
p |
Crawford,
1991 |
ACE |
199 |
80% |
NS |
12 m |
NS |
Idem + G |
72% |
11 m |
Trillet,
1993 |
ACE
|
130 |
87%
|
NS |
12 m
|
0,27 |
Idem + G |
79% |
11 m |
Hamm,
1994 |
ACE |
233 |
86% |
NS |
|
0,8 |
Idem + GM |
75% |
|
Bunn,
1995 |
CDDP-VP16
|
230 |
86% |
NS |
17 m |
0,15 |
Idem + GM |
73% |
14 m |
Steward,
1998 |
VICE
|
98 |
77%
|
NS |
|
|
Idem + GM |
78% |
|
Fukuoka,
1997 |
CODE
|
63 |
84%
|
0,07 |
8 m
|
0,004 |
Idem + G |
97% |
15 m |
Gatzemeier,
2000 |
ACE
|
280 |
79%
|
NS |
10 m
|
NS |
Idem + G |
76% |
11 m |
Références
(1) Crawford J, Ozer H, Stoller R, Johnson D, Lyman G, Tabbara I et al. Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. N Engl J Med 1991; 325(3):164-170.
(2) Trillet-Lenoir V, Green J, Manegold C, von Pawel J, Gatzemeier U, Lebeau B et al. Recombinant granulocyte colony stimulating factor reduces the infectious complications of cytotoxic chemotherapy. Eur J Cancer 1993; 29A(3):319-324.
(3) Trillet-Lenoir V, Green JA, Manegold C, von Pawel J, Gatzemeier U, Lebeau B et al. Recombinant granulocyte colony stimulating factor in the treatment of small cell lung cancer: a long-term follow-up [letter]. Eur J Cancer 1995; 31A(12):2115-2116.
(4) Hamm J, Schiller JH, Cuffie C, Oken M, Fisher RI, Shepherd F et al. Dose-ranging study of recombinant human granulocyte-macrophage colony- stimulating factor in small-cell lung carcinoma. J Clin Oncol 1994; 12(12):2667-2676.
(5) Bunn PAJ, Crowley J, Kelly K, Hazuka MB, Beasley K, Upchurch C et al. Chemoradiotherapy with or without granulocyte-macrophage colony- stimulating factor in the treatment of limited-stage small-cell lung cancer: a prospective phase III randomized study of the Southwest Oncology Group [published erratum appears in J Clin Oncol 1995 Nov;13(11):2860]. J Clin Oncol 1995; 13(7):1632-1641.
(6) Steward WP, von Pawel J, Gatzemeier U, Woll P, Thatcher N, Koschel G et al. Effects of granulocyte-macrophage colony-stimulating factor and dose intensification of V-ICE chemotherapy in small-cell lung cancer: a prospective randomized study of 300 patients. J Clin Oncol 1998; 16(2):642-650.
(7) Fukuoka M, Masuda N, Negoro S, Matsui K, Yana T, Kudoh S et al. CODE chemotherapy with and without granulocyte colony-stimulating factor in small-cell lung cancer. Br J Cancer 1997; 75(2):306-309.
(8) Gatzemeier U, Kleisbauer JP, Drings P, Kaukel E, Samaras N, Melo MJ et al. Lenograstim as support for ACE chemotherapy of small-cell lung cancer: a phase III, multicenter, randomized study. Am J Clin Oncol 2000; 23(4):393-400.
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