CANCERS BRONCHIQUES A PETITES CELLULES
MAINTIEN DE LA DOSE-INTENSITE PAR LES FACTEURS DE CROISSANCE

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Référence

Schéma

N pts

RO

p

SM

p

Crawford,

1991

ACE

199

80%

NS

12 m

NS

Idem + G

72%

11 m

Trillet,

1993

ACE

130

87%

 

NS

12 m

 

0,27

Idem + G

79%

11 m

Hamm,

1994

ACE

233

86%

NS

0,8

Idem + GM

75%

Bunn,

1995

CDDP-VP16

230

86%

NS

17 m

0,15

Idem + GM

73%

14 m

Steward,

1998

VICE

98

77%

NS

Idem + GM

78%

Fukuoka,

1997

CODE

63

84%

 

0,07

8 m

 

0,004

Idem + G

97%

15 m

Gatzemeier,

2000

ACE

280

79%

 

NS

10 m

 

NS

Idem + G

76%

11 m



Références

(1) Crawford J, Ozer H, Stoller R, Johnson D, Lyman G, Tabbara I et al. Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. N Engl J Med 1991; 325(3):164-170.

(2) Trillet-Lenoir V, Green J, Manegold C, von Pawel J, Gatzemeier U, Lebeau B et al. Recombinant granulocyte colony stimulating factor reduces the infectious complications of cytotoxic chemotherapy. Eur J Cancer 1993; 29A(3):319-324.

(3) Trillet-Lenoir V, Green JA, Manegold C, von Pawel J, Gatzemeier U, Lebeau B et al. Recombinant granulocyte colony stimulating factor in the treatment of small cell lung cancer: a long-term follow-up [letter]. Eur J Cancer 1995; 31A(12):2115-2116.

(4) Hamm J, Schiller JH, Cuffie C, Oken M, Fisher RI, Shepherd F et al. Dose-ranging study of recombinant human granulocyte-macrophage colony- stimulating factor in small-cell lung carcinoma. J Clin Oncol 1994; 12(12):2667-2676.

(5) Bunn PAJ, Crowley J, Kelly K, Hazuka MB, Beasley K, Upchurch C et al. Chemoradiotherapy with or without granulocyte-macrophage colony- stimulating factor in the treatment of limited-stage small-cell lung cancer: a prospective phase III randomized study of the Southwest Oncology Group [published erratum appears in J Clin Oncol 1995 Nov;13(11):2860]. J Clin Oncol 1995; 13(7):1632-1641.

(6) Steward WP, von Pawel J, Gatzemeier U, Woll P, Thatcher N, Koschel G et al. Effects of granulocyte-macrophage colony-stimulating factor and dose intensification of V-ICE chemotherapy in small-cell lung cancer: a prospective randomized study of 300 patients. J Clin Oncol 1998; 16(2):642-650.

(7) Fukuoka M, Masuda N, Negoro S, Matsui K, Yana T, Kudoh S et al. CODE chemotherapy with and without granulocyte colony-stimulating factor in small-cell lung cancer. Br J Cancer 1997; 75(2):306-309.

(8) Gatzemeier U, Kleisbauer JP, Drings P, Kaukel E, Samaras N, Melo MJ et al. Lenograstim as support for ACE chemotherapy of small-cell lung cancer: a phase III, multicenter, randomized study. Am J Clin Oncol 2000; 23(4):393-400.



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