|
CANCERS BRONCHIQUES A PETITES CELLULES
CHIMIOTHERAPIE A MEGADOSES: INTENSIFICATION TARDIVE
|
|
Référence
|
chimiothérapie
|
stade
|
nb pts
|
RO %
|
p
|
SM
|
p
|
Humblet,
1987 (1)
|
1. Standard
|
|
22
|
|
|
55 s
|
NS
|
2.
Intensification avec autogreffe de moelle
|
|
23
|
|
68 s
|
Lorigan,
2005 (2)
|
1.
Standard : Ifo (5) – Carbo (300) – VP16 (180 x 2) ttes les 4 sem
|
bon pronostic
|
159
|
88%
|
0,09
|
13,9 m
|
NS
|
2.
Intensifié : Ifo (5) – Carbo (300) – VP16 (180 x 2) ttes les 2 sem avec
filgrastine et greffe cellules souches
|
159
|
89%
|
14,4 m
|
Buchholz,
2007 (3)
|
1.
Standard : Ifo (5) – Carbo (300) – VP16 (180 x 2) ttes les 4 sem (6
cycles)
|
bon pronostic
|
41
|
88%
|
0,02
|
18,5 m
|
0,001
|
2.
Intensifié : Ifo (5) – Carbo (300) – VP16 (180 x 2) ttes les 2 sem avec
filgrastine et greffe cellules souches
|
42
|
100%
|
30,3 m
|
Références
(1) Humblet Y, Symann M,
Bosly A, Delaunois L, Francis C, Machiels J, et al. Late
intensification chemotherapy with autologous bone marrow transplantation in
selected small-cell carcinoma of the lung: a randomized study. J Clin Oncol
1987 Dec;5(12):1864-73.
(2) Lorigan P, Woll PJ, O'Brien ME, Ashcroft LF, Sampson MR, Thatcher
N. Randomized phase III trial of dose-dense chemotherapy supported by
whole-blood hematopoietic progenitors in better-prognosis small-cell lung
cancer. J Natl Cancer Inst 2005 May 4;97(9):666-74.
(3) Buchholz E, Manegold C, Pilz L, Thatcher N,
Drings P. Standard versus dose-intensified chemotherapy with sequential
reinfusion of hematopoietic progenitor cells in small cell lung cancer patients
with favorable prognosis. J Thorac Oncol 2007;2:51-7.
|