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CANCERS BRONCHIQUES NON A PETITES CELLULES AU STADE AVANCE ESSAIS TESTANT LE ROLE DE LA CHIMIOTHERAPIE SEQUENTIELLE
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|
référence
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chimiothérapie
|
n
|
(stIV)
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% RO
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p
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SM
|
p
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Edelman,
2004 (1)
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I. Carboplatine + gemcitabine puis
paclitaxel
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95
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80 %
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21
|
|
9 m
|
|
II.
Cisplatine + vinorelbine puis docétaxel
|
83
|
85 %
|
28
|
9 m
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Sculier,
2007(2)
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Cisplatine + gemcitabine +
ifosfamide (GIP) x 3 cycles ; if no progression
|
485
|
|
36
|
|
|
0,17
|
I. GIP
|
140
|
127
|
|
9,7 m
|
II. paclitaxel
|
141
|
126
|
|
11,9 m
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Grigorescu,
2007 (3)
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I. Gemci + vinorelbine x 2 puis
Ifo-gemci x 2
|
50
|
48 %
|
8
|
0,019
|
6,5 m
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0,16
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II. Gemci + cisplatine (70)
|
52
|
44 %
|
25
|
9,7 m
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Vergnenègre,
2009 (4) I
|
Cisplatine
(75) + gemcitabine 2 cycles : si non progression
|
228
|
|
|
|
|
|
I. Cisplatine (75) + gemcitabine
|
45
|
96 %
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16 %
|
|
11
m
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NS
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II
paclitaxel + gemcitabine
|
42
|
98 %
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21 %
|
10,7
m
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Références
(1) Edelman MJ, Clark JI, Chansky K, Albain K, Bhoopalam N, Weiss GR et al. Randomized phase II trial of sequential chemotherapy in advanced non-small cell lung cancer (SWOG 9806): carboplatin/gemcitabine followed by paclitaxel or cisplatin/vinorelbine followed by docetaxel. Clin Cancer Res 2004; 10(15):5022-5026.
(2) Sculier J, Lafitte J, Lecomte J, Alexopoulos C, Van CO, Giner V, et al. A phase III randomised trial comparing sequential chemotherapy using cisplatin-based regimen and paclitaxel to cisplatin-based chemotherapy alone in advanced non-small-cell lung cancer. Ann Oncol 2007 Jun;18(6):1037-42.
(3) Grigorescu A, Ciuleanu T, Firoiu E, Muresan DR, Teodorescu G, Basson BR. A randomized phase II trial of sequential gemcitabine plus vinorelbine followed by gemcitabine plus ifosfamide versus gemcitabine plus cisplatin in the treatment of chemo-naive patients with stages III and IV non-small cell lung cancer (NSCLC). Lung Cancer 2007 Aug;57(2):168-74.
(4) Vergnenegre A, Tillon J, Corre R, Barlesi F, Berard H, Vernejoux JM, et al. A randomized phase II trial assessing in advanced non-small cell lung cancer patients with stable disease after two courses of cisplatin-gemcitabine an early modification of chemotherapy doublet with paclitaxel-gemcitabine versus continuation of cisplatin-gemcitabine chemotherapy (GFPC 03-01 Study). J Thorac Oncol 2009 Mar;4(3):364-70.
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